Below is a list of all our publications to date. If you have any questions or would like to discuss the papers, please get in touch... we would love to hear from you.
Pragmatic physiologically-based pharmacokinetic modeling to support clinical implementation of optimized gentamicin dosing in term neonates and infants: proof-of-concept
Marika A. de Hoop-Sommen, Joyce E. M. van der Heijden,
Jolien J. M. Freriksen, Rick Greupink and Saskia N. de Wildt
Jolien J. M. Freriksen, Rick Greupink and Saskia N. de Wildt
Towards More Robust Evaluation of the Predictive Performance of Physiologically Based Pharmacokinetic Models: Using Confidence Intervals to Support Use of Model‑Informed Dosing in Clinical Care
Marjolein D. van Borselen, Laurens Auke Æmiel Sluijterman, Rick Greupink, Saskia N. de Wildt
Optimization of the betamethasone and dexamethasone dosing regimen during pregnancy: a combined placenta perfusion and pregnancy physiologically based pharmacokinetic modeling approach
Joyce E. M. Van Der Heijden, MSc; Hedwig Van Hove, MSc; Niki M. Van Elst, BSc; Petra Van Den Broek, BSc; Joris Van Drongelen, MD, PhD; Hubertina C. J. Scheepers, MD, PhD; Saskia N. De Wildt, MD, PhD; Rick Greupink, PharmD, PhD
Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept
Joyce E. M. van der Heijden, Marika de Hoop-Sommen, Noa Hoevenaars, Jolien J. M. Freriksen, Koen Joosten, Rick Greupink and Saskia N. de Wildt
Demystifying physiologically based pharmacokinetic modelling among non-modelers towards model-informed medicine use in under-served populations
Jolien Freriksen, Joyce van der Heijden, Marika de Hoop-Sommen, Trevor Johnson, Karen R Yeo, Essam Kerwash, Susan Cole, Janet Nooney, Rick Greupink, Ping Zhao, Saskia de Wildt
Perceived barriers and facilitators for model‑informed dosing in pregnancy: a qualitative study across healthcare practitioners and pregnant women
Charlotte Koldeweij, Mirèse Kleuskens, Carlijn Litjens, Bryony Dean Franklin, Hubertina C. J. Scheepers and Saskia N. de Wildt
Willingness-to-use and preferences for model-informed antenatal doses: a cross-sectional study among European healthcare practitioners and pregnant women
C. J. M. Koldeweij, A. C. Dibbets, M. Ceulemans, L. C. de Vries, B. D. Franklin, H. C. J. Scheepers and S. N. de Wildt
A User-Driven Framework for Dose Selection in Pregnancy: Proof of Concept for Sertraline
Charlotte Koldeweij, Caroline Dibbets, Bryony D. Franklin, Hubertina C. J. Scheepers and Saskia N. de Wildt
Barriers and Facilitators for Bringing Model-Informed Precision Dosing to the Patient’s Bedside: A Systematic Review
Anna Caroline Dibbets, Charlotte Koldeweij, Esra P. Osinga, Hubertina C. J. Scheepers and Saskia N. de Wildt
A User-Driven Framework for Dose Selection in Pregnancy: Proof of Concept for Sertraline
Charlotte Koldeweij, Caroline Dibbets, Bryony D. Franklin, Hubertina C. J. Scheepers, and Saskia N. de Wildt
Abstract: Despite growing knowledge of pregnancy-induced changes in physiology that may alter maternal and fetal pharmacokinetics, evidence-based antenatal doses are lacking for most drugs. Pharmacokinetic modeling and expanding clinical data in pregnancy may support antenatal doses. We aimed to develop and pilot a comprehensive and user-driven Framework for Dose Selection in Pregnancy to support the clinical implementation of a best-evidence antenatal dose for sertraline...