Ready to implement

 

Go straight to Lareb’s official MID recommendations. These dosing regimens have been reviewed by clinicians, pharmacists, and pharmacology experts, and are ready for safe implementation in daily care.

 


Further information

  • Medication specific details: Read the summary or full Dosing recommendation Document per each endorsed medication
  • PBPK guidance: link to PBKP learning tools?
  • Model-informed Dosing: link to Modelers webpage?
  • Scientific literature: browse through all our peer-reviewed publications

References

  1. Westin AA, Reimers A, Spigset O. Should pregnant women receive lower or higher medication doses? Tidsskr Nor Laegeforen. 2018 Oct 30;138(17). English, Norwegian. doi: 10.4045/tidsskr.18.0065. PMID: 30378417.
  2. Kazma JM, van den Anker J, Allegaert K, Dallmann A, Ahmadzia HK. Anatomical and physiological alterations of pregnancy. J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):271-285. doi: 10.1007/s10928-020-09677-1. Epub 2020 Feb 6. PMID: 32026239; PMCID: PMC7416543.
  3. Abduljalil K, Furness P, Johnson TN, Rostami-Hodjegan A, Soltani H. Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling. Clin Pharmacokinet. 2012 Jun 1;51(6):365-96. doi: 10.2165/11597440-000000000-00000. PMID: 22515555.
  4. Pinheiro EA, Stika CS. Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care. Semin Perinatol. 2020 Apr;44(3):151221. doi: 10.1016/j.semperi.2020.151221. Epub 2020 Jan 25. PMID: 32115202; PMCID: PMC8195457.
  5. van Donge T, Evers K, Koch G, van den Anker J, Pfister M. Clinical Pharmacology and Pharmacometrics to Better Understand Physiological Changes During Pregnancy and Neonatal Life. Handb Exp Pharmacol. 2020;261:325-337. doi: 10.1007/164_2019_210. PMID: 30968215.
  6. Eke AC. An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics. J Basic Clin Physiol Pharmacol. 2021 Dec 8;33(5):581-598. doi: 10.1515/jbcpp-2021-0312. PMID: 34881531; PMCID: PMC9174343.
  7. Koren G, Pariente G. Pregnancy- Associated Changes in Pharmacokinetics and their Clinical Implications. Pharm Res. 2018 Feb 12;35(3):61. doi: 10.1007/s11095-018-2352-2. PMID: 29435666.
  8. Pariente G, Leibson T, Carls A, Adams-Webber T, Ito S, Koren G. Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review. PLoS Med. 2016 Nov 1;13(11):e1002160. doi: 10.1371/journal.pmed.1002160. PMID: 27802281; PMCID: PMC5089741.
  9. Pacifici GM, Nottoli R. Placental transfer of drugs administered to the mother. Clin Pharmacokinet. 1995;28(3):235–69. Available from: http://dx.doi.org/10.2165/00003088-199528030-00005

 

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