Ready to implement

 

Go to Lareb’s official MID recommendations. These dosing regimens have been reviewed by clinicians, pharmacists, and pharmacology experts, and are ready for safe implementation in daily care.

 


Further information

  • PBPK knowledge: find out more with our upcoming short course on PBPK modelling
  • Scientific literature: browse through all our peer-reviewed publications

References

 

  1. Schrier L, Hadjipanayis A, Stiris T, Ross-Russell RI, Valiulis A, Turner MA, et al. Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology. Eur J Pediatr. 2020;179(5):839-47. 
  1. Wisner KL, Stika CS, Watson K. Pregnant women are still therapeutic orphans. World Psychiatry. 2020;19(3):329-30. 
  1. Koren G, Pariente G. Pregnancy- Associated Changes in Pharmacokinetics and their Clinical Implications. Pharm Res. 2018;35(3):61. 
  1. Westin AA, Reimers A, Spigset O. Should pregnant women receive lower or higher medication doses? Tidsskr Nor Laegeforen. 2018 Oct 30;138(17). English, Norwegian. doi: 10.4045/tidsskr.18.0065. PMID: 30378417. 
  1. Kazma JM, van den Anker J, Allegaert K, Dallmann A, Ahmadzia HK. Anatomical and physiological alterations of pregnancy. J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):271-285. doi: 10.1007/s10928-020-09677-1. Epub 2020 Feb 6. PMID: 32026239; PMCID: PMC7416543. 
  1. Abduljalil K, Furness P, Johnson TN, Rostami-Hodjegan A, Soltani H. Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling. Clin Pharmacokinet. 2012 Jun 1;51(6):365-96. doi: 10.2165/11597440-000000000-00000. PMID: 22515555. 
  1. Pinheiro EA, Stika CS. Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care. Semin Perinatol. 2020 Apr;44(3):151221. doi: 10.1016/j.semperi.2020.151221. Epub 2020 Jan 25. PMID: 32115202; PMCID: PMC8195457. 
  1. van Donge T, Evers K, Koch G, van den Anker J, Pfister M. Clinical Pharmacology and Pharmacometrics to Better Understand Physiological Changes During Pregnancy and Neonatal Life. Handb Exp Pharmacol. 2020;261:325-337. doi: 10.1007/164_2019_210. PMID: 30968215. 
  1. Eke AC. An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics. J Basic Clin Physiol Pharmacol. 2021 Dec 8;33(5):581-598. doi: 10.1515/jbcpp-2021-0312. PMID: 34881531; PMCID: PMC9174343. 
  1. Koren G, Pariente G. Pregnancy- Associated Changes in Pharmacokinetics and their Clinical Implications. Pharm Res. 2018 Feb 12;35(3):61. doi: 10.1007/s11095-018-2352-2. PMID: 29435666. 
  1. Pariente G, Leibson T, Carls A, Adams-Webber T, Ito S, Koren G. Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review. PLoS Med. 2016 Nov 1;13(11):e1002160. doi: 10.1371/journal.pmed.1002160. PMID: 27802281; PMCID: PMC5089741. 
  1. Pacifici GM, Nottoli R. Placental transfer of drugs administered to the mother. Clin Pharmacokinet. 1995;28(3):235–69. Available from: http://dx.doi.org/10.2165/00003088-199528030-00005 
  1. Freriksen JJM, van der Heijden JEM, de Hoop-Sommen MA, Greupink R, de Wildt SN. Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population. Paediatr Drugs. 2023;25(1):5-11 
  1. van der Heijden JEM, Freriksen JJM, de Hoop-Sommen MA, Greupink R, de Wildt SN. Physiologically-Based Pharmacokinetic Modeling for Drug Dosing in Pediatric Patients: A Tutorial for a Pragmatic Approach in Clinical Care. Clin Pharmacol Ther. 2023;114(5):960-71 
  1. Sager JE, Yu J, Ragueneau-Majlessi I, Isoherranen N. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification. Drug Metab Dispos. 2015;43(11):1823-37 
  1. Verscheijden LFM, Koenderink JB, Johnson TN, de Wildt SN, Russel FGM. Physiologically-based pharmacokinetic models for children: Starting to reach maturation? Pharmacol Ther. 2020;211:107541. 
  1. Kuemmel C, Yang Y, Zhang X, Florian J, Zhu H, Tegenge M, et al. Consideration of a Credibility Assessment Framework in Model-Informed Drug Development: Potential Application to Physiologically-Based Pharmacokinetic Modeling and Simulation. CPT Pharmacometrics Syst Pharmacol. 2020;9(1):21-8. 
  1. van der Zanden TM, Mooij MG, Vet NJ, Neubert A, Rascher W, Lagler FB, et al. Benefit-Risk Assessment of Off-Label Drug Use in Children: The Bravo Framework. Clin Pharmacol Ther. 2021;110(4):952-65. 

 

 

 

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