Model-informed dosing in pregnancy
Evidence-based doses
From the simulation results, a dosing regimen is selected that meets the pharmacokinetic target for most of the virtual population while avoiding levels that are too low (risking treatment failure) or too high (risking toxicity). Any model-informed dosing recommendation is reviewed by clinicians, pharmacists, and other experts to ensure it is safe, practical, and supported by other evidence. Considerations include:
• How different the dose is from current practice
• Whether the regimen is feasible in real-world care
• How to monitor drug levels or clinical response if needed
• The consequences if predictions are wrong
Whether you’re ready to adjust dosing today or you want to explore the science behind the recommendations, there are several ways to engage with model-informed dosing (MID) for pregnancy.